"May evolution have no mercy on your descendants."

Or

"May evolution have no mercy on your genes."

Or something to that affect. Any suggestions?

May the catalytic organisms devour your flesh with rapid efficiency

I prefer the Chaos Theory Curse: May the fluttering of a butterfly's wings send a typhoon into your family's trailer park.

"May Cthulhu eat you first"

Inverse Trust Theory: The more someone says, "Trust Me", the more likely you are to get screwed. CNN says, "Trust Lou Dobbs" so much, he's gotta be a baby-eater. Yum... Babies!

I've always liked, "May Natural Selection Run Its Course", but they never get it.

Or, "May [insert deity here] have [insert dogma here] on your [insert transcendental vessel here]."

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